[Endothelial cell senescence in human atherosclerosis: role of telomeres in endothelial dysfunction].

@article{Minamino2003EndothelialCS,
  title={[Endothelial cell senescence in human atherosclerosis: role of telomeres in endothelial dysfunction].},
  author={Tohru Minamino and Hideyuki Miyauchi and Toshihiko Yoshida and Issei Komuro},
  journal={Journal of cardiology},
  year={2003},
  volume={41 1},
  pages={39-40}
}
BACKGROUND The functional changes associated with cellular senescence may be involved in human aging and age-related vascular disorders. We have shown the important role of telomeres and telomerase in vascular cell senescence in vitro. Progressive telomere shortening in vivo has been observed in the regions susceptible to atherosclerosis, implicating its contributions to atherogenesis. However, whether senescent vascular cells are present in the vascularture and contribute to the pathogenesis… CONTINUE READING

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