[Endothelial (dys)function in the experimental model of primary hypertension].

  title={[Endothelial (dys)function in the experimental model of primary hypertension].},
  author={Angelika Puzserova and Jana Kopincov{\'a} and Iveta Bernatova},
  journal={Ceskoslovenska fysiologie},
  volume={59 1},
A number of vascular diseases, including hypertension, are characterised by endothelial dysfunction caused by alterations in the production and action of the endothelium-derived relaxing (EDRFs) and/or endothelium-derived contracting (EDCFs) factors. The spontaneously hypertensive rat (SHR) is one of the most widely studied animal models for human essential hypertension. Several similarities between human primary hypertension and hypertension in the SHR have been pointed out in both the… CONTINUE READING