[Effects of various ginkgo biloba extracts and proanthocyanidin on hepatic cytochrome P450 activity in rats].

@article{Sugiyama2004EffectsOV,
  title={[Effects of various ginkgo biloba extracts and proanthocyanidin on hepatic cytochrome P450 activity in rats].},
  author={T. Sugiyama and K. Shinozuka and A. Sano and S. Yamada and K. Endoh and K. Yamada and K. Umegaki},
  journal={Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan},
  year={2004},
  volume={45 6},
  pages={
          295-301
        }
}
  • T. Sugiyama, K. Shinozuka, +4 authors K. Umegaki
  • Published 2004
  • Chemistry, Medicine
  • Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan
  • In previous papers, we showed that Ginkgo biloba extract (GBE) induced hepatic cytochrome P450 (CYP) activity, in particular pentoxyresorufin O-dealkylase (PROD; corresponding to CYP2B type) in rats, and that GBE influenced the efficacy of co-administered drugs. In this study, to clarify the nature of the induction, we examined the effects of GBE samples from different sources and some major constituents of GBE on rat hepatic CYP in vitro and in vivo. In the study in vitro, eight GBE samples… CONTINUE READING
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