[Effects of tumor necrosis factor alpha on proteolysis of respiratory muscles in rats with chronic obstructive pulmonary disease].

@article{Sun2007EffectsOT,
  title={[Effects of tumor necrosis factor alpha on proteolysis of respiratory muscles in rats with chronic obstructive pulmonary disease].},
  author={Sheng-hua Sun and Wen-xiang Tang and Chun Liu and Hua Lin and Hong-hui Yang},
  journal={Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases},
  year={2007},
  volume={30 3},
  pages={
          186-91
        }
}
OBJECTIVE To investigate the impact of tumor necrosis factor alpha (TNF-alpha) on proteolysis of respiratory muscles in rats with chronic obstructive pulmonary disease (COPD). METHODS Ninety healthy male adult Wistar rats were randomly divided into two groups: a normal control group (n = 20) and a model group (n = 70). The COPD rat model was established by intratracheal instillation of porcine pancreatic elastase and exposure to cigarette smoke for 60 days. Malnutrition was defined as the… CONTINUE READING

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