[Effects of the Combination of Emodin and 3'-Azido-3'-Deoxythymidine on Proliferation and Apoptosis in leukemia KG-1a cells Transfected with Egr-1 siRNA].

@article{Yuan2015EffectsOT,
  title={[Effects of the Combination of Emodin and 3'-Azido-3'-Deoxythymidine on Proliferation and Apoptosis in leukemia KG-1a cells Transfected with Egr-1 siRNA].},
  author={Lingyan Yuan and Che Chen and Hui-yuan Chu and Y. Liu},
  journal={Zhongguo shi yan xue ye xue za zhi},
  year={2015},
  volume={23 2},
  pages={
          386-91
        }
}
  • Lingyan Yuan, Che Chen, +1 author Y. Liu
  • Published 2015
  • Medicine, Biology
  • Zhongguo shi yan xue ye xue za zhi
  • OBJECTIVE This study was aimed to investigate the effects of emodin combined with 3'-azido-3'-deoxythymidine (AZT) on proliferation and apoptosis of leukemia cell line KG-1a cells and its mechanism. METHODS KG-1a cells were transfected with Egr-1 siRNA by electroporation and divided into blank control (KG-1a), nonspecific control (KG-1a/NC) and Egr-1 siRNA (KG-1a/siRNA) groups. Transfection efficiency was tested through fluorescence microscopy and flow cytometry and the transfection effect… CONTINUE READING
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