[Effects of reserpine and 5-HT on analgesia induced by lappaconitine and N-deacetyllappaconitine].

@article{Guo1990EffectsOR,
  title={[Effects of reserpine and 5-HT on analgesia induced by lappaconitine and N-deacetyllappaconitine].},
  author={Xue-wu Guo and Xi Can Tang},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1990},
  volume={11 1},
  pages={14-8}
}
In the rat tail-flick test it was shown that ip lappaconitine (LA) 1-6 mg/kg, N-deacetyllappaconitine (DLA) 4-10 mg/kg or icv DLA 20-60 micrograms/rat exhibited a dose-dependent analgesic activity, but icv LA 20-40 micrograms/rat was inactive. The analgesic potency of ip LA was a little more potent than that of DLA and slightly weaker than that of morphine (P less than 0.05). Combined ip of subanalgesic doses of morphine and LA or DLA produced significant analgesic action. Analgesia mediated by… CONTINUE READING