[Effects of propofol on contractility and electrophysiological properties of canine single cardiomyocytes].

@article{Shibuya1996EffectsOP,
  title={[Effects of propofol on contractility and electrophysiological properties of canine single cardiomyocytes].},
  author={Nobuko Shibuya and Akiko Higuchi and Noboru Hatakeyama and Mitsuaki Yamazaki and Yushi Ito and Yasunori Momose},
  journal={Masui. The Japanese journal of anesthesiology},
  year={1996},
  volume={45 4},
  pages={408-14}
}
We assessed the effects of propofol on contraction, action potentials and Ca2+ currents (Ica) in single ventricular cells in dog. Low concentrations of propofol 10(-5)M had no effects on contractile responses, but high doses above 10(-4)M of propofol decreased contractions. Propofol 10(-3)M reduced the duration of action potentials (time to 90% repolarization). Ica was decreased by propofol 10(-4)M without accompanying use-dependent manner. The present study indicates that clinical… CONTINUE READING