[Effects of polysomy 17 on HER-2 gene and protein expression and its clinicopathologic significance in breast cancer].


OBJECTIVE To explore the effects of polysomy 17 on human epidermal growth factor receptor-2 (HER-2) testing and study its clinicopathologic significance. METHODS We retrospectively analyzed the HER-2 status by fluorescence in situ hybridization (FISH) and HER-2 protein expression by immunohistochemistry (IHC) in a cohort of 619 patients with invasive… (More)