• Corpus ID: 9223624

[Effects of new antineoplastic agents (dimethoxybenflurone and Oracin) on the cardiovascular system and other parameters in the rabbit in vivo].

@article{Machckov2000EffectsON,
  title={[Effects of new antineoplastic agents (dimethoxybenflurone and Oracin) on the cardiovascular system and other parameters in the rabbit in vivo].},
  author={Jarmila Mach{\'a}ckov{\'a} and Vladimír Geršl and Michaela Adamcov{\'a} and Yvona Mazurov{\'a} and Radom{\'i}r Hrdina and Milan Mělka and Milan Nobilis},
  journal={Acta medica (Hradec Kralove). Supplementum},
  year={2000},
  volume={43 2},
  pages={
          119-38
        }
}
Anthracycline derivatives belong among the most effective antineoplastic drugs but their therapeutic use is limited by their side effects--a dose-related cardiotoxicity. The influence of repeated i.v. administration (once weekly, max. 10 weeks) of new antineoplastic agents--dimethoxybenfluron (DMB) (3,9-dimethoxybenfluron hydrochloride, C23H24O4NCl, M.w. 413.9, Institute of Experimental Biopharmaceutics, Czech Academy of Sciences, Hradec Králové, Czech Republic; 12 or 24 mg base/kg) and Oracin… 
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