[Effects of m-nisoldipine on arterial baroreflex sensitivity in anesthetized rats].

@article{Zhang1994EffectsOM,
  title={[Effects of m-nisoldipine on arterial baroreflex sensitivity in anesthetized rats].},
  author={Y L Zhang and Sherleen X Fu and Yong Sheng Li},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1994},
  volume={15 5},
  pages={466-9}
}
Baroreflex sensitivity (BRS) in anesthetized rats was measured as the slope of the regression line of the concomitant maximal change in heart rate (delta R-R) and blood pressure (delta BP) induced by bolus i.v. phenylephrine or sodium nitroprusside, m-nisoldipine (m-Nis) i.v. 5, 10, 20 micrograms.kg-1 depressed the BRS (2.6 +/- 0.2, 2.4 +/- 0.3, 1.6 +/- 0.2, or 1.7 +/- 0.1, 1.6 +/- 0.2, and 1.4 +/- 0.2 ms.kPa-1, respectively) compared with before medication (P < 0.01). m-Nis may act directly on… CONTINUE READING