[Effects of lithium on the activity of ERK-1/2 signal pathway and expression of Bcl-2 family proteins in the central nervous system in vivo].

Abstract

OBJECTIVE To investigate the effects of chronic in vivo lithium administration on ERK-1/2 signal pathway and the expression of Bcl-2 family proteins, and to elucidate the molecular mechanisms underlying the therapeutic effects of lithium on the manic depression. METHODS Forty male Wistar rats were evenly divided into 2 groups. One group was treated with 2… (More)

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