[Effects of intravenous immunoglobulin upon the overexpression and over-activation of nuclear factor-κB and matrix metalloproteinase-9 in murine model of Kawasaki disease].

@article{Shangguan2014EffectsOI,
  title={[Effects of intravenous immunoglobulin upon the overexpression and over-activation of nuclear factor-κB and matrix metalloproteinase-9 in murine model of Kawasaki disease].},
  author={Wen Shangguan and Zhongdong Du and Haiming Yang and Yanlan Zhang and Mingjing Song and Wenhua Dong},
  journal={Zhonghua yi xue za zhi},
  year={2014},
  volume={94 12},
  pages={938-43}
}
OBJECTIVE To explore the changes of expression and biological activity of nuclear factor-kappa B (NF-κB) and matrix metalloproteinase-9 (MMP-9) after using intravenous immunoglobulin (IVIG) in a murine model of Kawasaki disease (KD) and elucidate the therapeutic mechanism of IVIG for the treatment of KD. METHODS A total of 72 mice were categorized randomly into IVIG, KD and control groups.Lactobacillus casei cell wall extract (LCWE) was prepared and injected intraperitoneally into C57BL/6… CONTINUE READING
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