[Effects of intrathecal injection PI3K antagonist on inflammatory cytokines in spinal cord of bone cancer pain model in rats].

Abstract

OBJECTIVE To investigate the roles of PI3K in bone cancer pain, the present study was performed to demonstrate the changes of pain-related behavior and the production of IL-1β, IL-6 and TNF-α after intrathecal injection of wortmannin (antagonist of PI3K receptors) in rat model. METHODS A total of 44 SD rats were randomly divided into 4 groups, sham group… (More)
DOI: 10.3760/cma.j.issn.0376-2491.2016.04.015

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