• Biology, Medicine
  • Published in
    Nan fang yi ke da xue xue bao…
    2016

[Effects of exendin-4 on extracellular matrix metabolism in human mesangial cells cultured in high glucose].

@article{Xiao2016EffectsOE,
  title={[Effects of exendin-4 on extracellular matrix metabolism in human mesangial cells cultured in high glucose].},
  author={Zhi-Zhou Xiao and Mei-Ping Guan and Zong-ji Zheng and Yi-Jie Jia and Ling Wang and Yao-Ming Xue},
  journal={Nan fang yi ke da xue xue bao = Journal of Southern Medical University},
  year={2016},
  volume={36 3},
  pages={
          371-4
        }
}
OBJECTIVE To explore effects of exendin-4 on the metabolism of extracellular matrix (ECM) in human mesangial cells (HMC) cultured in the presence of high glucose and explore the possible mechanism. METHODS Human mesangial cells (HMC) were treated with exendin-4 under high glucose conditions. The cell proliferation was observed using CCK8 assay, and the expressions of collagen type I, fibronectin, transforming growth factor-β1 (TGFβ1) expression and extracellular signal- regulated kinase (ERK… CONTINUE READING