Corpus ID: 40225557

[Effects of dopamine receptor agonists and antagonists on cocaine-induced behaviors in rats].

@article{Minematsu1994EffectsOD,
  title={[Effects of dopamine receptor agonists and antagonists on cocaine-induced behaviors in rats].},
  author={N. Minematsu and I. Ushijima and N. Obara and Y. Mizuki and M. Yamada},
  journal={Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology},
  year={1994},
  volume={14 1},
  pages={
          27-32
        }
}

N. Minematsu, I. Ushijima, +2 authors M. Yamada

Published 1994

Chemistry, Medicine

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology

In this study, cocaine (5-20 mg/kg), an indirect dopamine agonist, increased locomotor activity and rearing accompanied with head circling and body shaking in a dose-dependent manner. A high dose of cocaine (40 mg/kg), meaning a toxic dose, slightly induced sniffing and licking. Both SCH23390, a D-1 receptor antagonist, and raclopride, a D-2 antagonist, inhibited all behaviors induced by cocaine, suggesting that the behavioral actions of cocaine may involve the activation of D-1 and D-2… CONTINUE READING

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