• Corpus ID: 19691675

[Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs].

@article{Li2009EffectsOC,
  title={[Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs].},
  author={Miaoling Li and Xiao-rong Zeng and Yan Yang and Jun-Rong Du},
  journal={Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition},
  year={2009},
  volume={40 5},
  pages={
          834-8
        }
}
  • Miaoling LiXiao-rong Zeng Jun-Rong Du
  • Published 1 September 2009
  • Medicine, Biology, Chemistry
  • Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
OBJECTIVE To test the effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs. METHODS Under the stimulation of different frequencies (0.2, 0.5, 1.0, 1.25 or 2.0 Hz), the action potential of papillary muscles in guinea pigs was recorded with the standard microelectrode techniques. The impacts of different concentrations of amiodarone (1, 5 or 10 micromol/L), dofetilide (10, 50, 100 nmol/L), and a combination of 100 nmol/L dofetilide and…