• Medicine
  • Published in
    Comptes rendus de l'Academie…
    1984

[Effects of adrenal medullectomy and passive immunization with an anti-CRF antiserum on the corticotropin secretion in response to stress in Long-Evans rats].

@article{Rey1984EffectsOA,
  title={[Effects of adrenal medullectomy and passive immunization with an anti-CRF antiserum on the corticotropin secretion in response to stress in Long-Evans rats].},
  author={Max Rey and Viviane Guillaume and Bernard Conte-Devolx and Guilaine Mercier and Françoise Boudouresque and Michel Grino and Charles Oliver},
  journal={Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie},
  year={1984},
  volume={299 12},
  pages={
          515-20
        }
}
Ether stress-induced ACTH and corticosterone secretion is similar in 60 days adrenal medullectomized and intact Long-Evans Rats. Passive immunisation with a 41-CRF antiserum impairs corticotropic function after stress. This decrease is more pronounced in adrenal medullectomized than in intact animals. These results suggest that epinephrine plays a minor role on the stress induced ACTH secretion. This role can be demonstrated only after immunoneutralisation of endogenous 41-CRF.