[Effects of Ginkgo biloba extract on the expression of eNOS and the release of NO in mesenteric arterioles of senile rats].

  title={[Effects of Ginkgo biloba extract on the expression of eNOS and the release of NO in mesenteric arterioles of senile rats].},
  author={Yan-hua Chang and Yong-Gang Chen and Guoping Yang},
  journal={Zhonghua yi xue za zhi},
  volume={91 35},
OBJECTIVE To investigate the effects of Ginkgo biloba extract (GBE) on the expression of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) in mesenteric arterioles of aging rats. METHODS (1) Cytologic experiment:human umbilical vein endothelial cells (HUVEC) were randomly divided into 3 groups: control group, NG-nitro-L-arginine methyl ester (L-NAME) group and GBE group. L-NAME group: 100 µmol/L L-NAME was added into HUNEC for a 48-hour incubation. GBE group: After… Expand
Protective effect of the standardized leaf extract of Ginkgo biloba (EGb761) against hypertension-induced renal injury in rats
EGb761 has the ability to protect against hypertension-induced renal injury and enhanced losartan effects on renal tissues oxidative stress, nitrite, and inflammatory markers levels and on protein expressions of eNOS, iNOS), TNF-α, IL-6 and IL-1B. Expand
Ginkgo biloba Extract Protects Mesenteric Arterioles of Old Rats via Improving Vessel Elasticity through Akt/FoxO3a Signaling Pathway.
This is the first report to indicate that GBE might exert protective effect on mesenteric arterioles of old rats via improving vascular elasticity and Akt/FoxO3a signaling pathway might be involved in this action. Expand
Protective effect of the standardized extract of ginkgo biloba (EGb761) against hypertension with hypercholesterolemia-induced renal injury in rats: Insights in the underlying mechanisms.
The ability of EGb761 to provide this renoprotective effect may positively correlate, besides its antihypertensive and antihypercholesterolemic effects, to its ability to suppress renal oxidative stress, nitrosative stress and inflammation. Expand
In vivo protective effects of Ginkgo biloba L. leaf extract against hydrogen peroxide toxicity: cytogenetic and biochemical evaluation
It has been determined that GbE treatment decreases the clastogenic effects of H 2 O 2 and reduces the MN and CAs frequency and causes a re-increase in mitotic cell numbers, and can be used as an antioxidant nutritional supplement to protect against the toxic effects of environmental agents such as H2 O 2. Expand
Pharmacologic treatments in preclinical tinnitus models with special focus on Ginkgo biloba leaf extract EGb 761®
This review will give a brief overview about preclinical models, presenting the heterogeneity of tinnitus sub-types depending on the different inner ear and brain structures involved in tinnitis etiology and pathogenesis, and providing an extensive overview on preclinical drug-based therapeutic approaches that have been explored in various animal models. Expand