[Effects of GBE50 on LPS/ATP induced NLRP3 inflammasome activation in primary rat microglia].

@article{Liu2018EffectsOG,
  title={[Effects of GBE50 on LPS/ATP induced NLRP3 inflammasome activation in primary rat microglia].},
  author={Fu-Qun Liu and Q. Gao and Dan-dan Wang and Z. Zhang},
  journal={Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica},
  year={2018},
  volume={43 16},
  pages={
          3346-3352
        }
}
  • Fu-Qun Liu, Q. Gao, +1 author Z. Zhang
  • Published 2018
  • Chemistry, Medicine
  • Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
In this study, the anti-inflammatory mechanism of Ginkgo biloba extract 50 (GBE50) and its mechanism of action on NLRP3 inflammatory corpuscles were observed by primary microglia cells. LPS/ATP was used to stimulate microglia, and the best time for stimulation and optimal concentration of GBE50 were screened. Pro-inflammatory cytokine IL-1β and TNF-α was determined by ELISA. Western blot was performed to observe the protein expression of NLRP3, ASC, caspase-1 and IL-1β in cultured primary rat… Expand
4 Citations