[Effects of E-3123, a new protease inhibitor, on several protease activities and on experimental acute pancreatitis].

@article{Miyamoto1988EffectsOE,
  title={[Effects of E-3123, a new protease inhibitor, on several protease activities and on experimental acute pancreatitis].},
  author={Kaname Miyamoto and Ieharu Hishinuma and Junichi Nagakawa and Naoko Nagaoka and Takashi Yamanaka and Tsuneo Wakabayashi},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  year={1988},
  volume={91 5},
  pages={
          285-93
        }
}
4-(2-Succinimidoethylthio) phenyl 4-guanidinobenzoate (E-3123) potently inhibited trypsin, plasmin and thrombin with IC50 values of 3.9 x 10(-8) M, 9.5 x 10(-7) M and 1.9 x 10(-6) M, respectively. Experimental acute pancreatitis was induced by injection of a mixture of trypsin and taurocholate into the pancreas in rats and rabbits or by an application of a closed duodenal loop in dogs. Intravenous infusion of E-3123 at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduced mortality… 
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