[Effectiveness of captopril in severe hypertension (author's transl)].

  title={[Effectiveness of captopril in severe hypertension (author's transl)].},
  author={François Elkik and A. Lemos Monteiro and Pierre Corvol and Paul Milliez},
  journal={La Nouvelle presse medicale},
  volume={10 19},
Fifteen patients with severe essential or renal hypertension were treated with captopril. In thirteen, a single oral dose of 1 mg/kg produced a mean fall of 20.7 +/- 16.42 mmHg (18%) in mean arterial pressure (MAP) without concomitant increase in heart rate. The fall was significant at 20 minutes and maximum at 90 minutes on average. It correlated closely with the initial plasma renin activity (PRA) (r = 0.96) and with the increase in PRA under treatment (r = 0.75). After an 8-day treatment… CONTINUE READING