Corpus ID: 40706280

[Effect on animal tumors and toxicity of lycobetaine acetate (author's transl)].

@article{Zhang1981EffectOA,
  title={[Effect on animal tumors and toxicity of lycobetaine acetate (author's transl)].},
  author={S. Zhang and F. Lu and J. L. Yang and L. Wang and B. Xu},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1981},
  volume={2 1},
  pages={
          41-5
        }
}

S. Zhang, F. Lu, +2 authors B. Xu

Published 1981

Chemistry, Medicine

Zhongguo yao li xue bao = Acta pharmacologica Sinica

Lycobetaine, a derivative of lycorine, is a new type of antitumor drug. When lycobetaine acetate (AT-1840) was given ip to mice and rats inoculated with Ehrlich ascites carcinoma, ascites hepatoma, leukemia L-1210, leukemia P-388, Lewis lung cardinoma or Yoshida ascites sarcoma, the survival times of the tumor-bearing animals were prolonged significantly. Lycorine exhibited only negligible effect on the above-mentioned tumors. The acute ip LD50 of AT-1840 in mice was 72 mg/kg. In dogs iv 3 or… CONTINUE READING

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