[Effect of the synthetic cannabinoid dronabinol on central pain in patients with multiple sclerosis--secondary publication].

@article{Svendsen2005EffectOT,
  title={[Effect of the synthetic cannabinoid dronabinol on central pain in patients with multiple sclerosis--secondary publication].},
  author={Kristina Bacher Svendsen and Troels S Jensen and Flemming Winther Bach},
  journal={Ugeskrift for laeger},
  year={2005},
  volume={167 25-31},
  pages={
          2772-4
        }
}
Cannabinoids reduce allodynia/hyperalgesia in animal pain models, but few clinical studies evaluated the analgesic action in humans. We aimed to evaluate the effect of delta-9-tetrahydrocannabinol (dronabinol) on central pain in MS patients. Twenty-four MS patients participated in a double-blind placebo-controlled crossover trial. Dronabinol reduced the spontaneous pain intensity significantly compared with placebo (4.0 (2.3-6.0) vs. 5.0 (4.0-6.4), median (25th-75th percentiles), p = 0.02… CONTINUE READING

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