[Effect of selective phosphodiesterase 4 inhibitors on nuclear factor kappa B, tumor necrosis factor-α and interleukin-8 expression in peripheral blood mononuclear cells in rheumatoid arthritis with interstitial lung disease].

@article{Song2013EffectOS,
  title={[Effect of selective phosphodiesterase 4 inhibitors on nuclear factor kappa B, tumor necrosis factor-α and interleukin-8 expression in peripheral blood mononuclear cells in rheumatoid arthritis with interstitial lung disease].},
  author={Ning ning Song and Ai-jing Liu and Xue-feng Gao and Xian-li Guo and Ji-tao Guan and Jian-ling Wu and Rui-fang Zhang and Lin Duan and Wen-shu He},
  journal={Zhonghua nei ke za zhi},
  year={2013},
  volume={52 10},
  pages={829-32}
}
OBJECTIVE To investigate the effect of selective phosphodiesterase (PDE) 4 inhibitors on nuclear factor kappa B (NF-κB), tumor necrosis factor-α (TNFα) and interleukin-8 (IL-8) secreted by peripheral blood mononuclear cells (PBMCs) in patients diagnosed as rheumatoid arthritis with interstitial lung disease (RA-ILD). METHODS PBMCs isolated from 15 healthy volunteers (group A) and 20 patients with untreated active RA-ILD (group B) were cultured in vitro. PBMCs from healthy subjects were… CONTINUE READING