Corpus ID: 22393854

[Effect of pyrazolone derivatives on the level of reduced glutathione in rat liver].

@article{Bien1983EffectOP,
  title={[Effect of pyrazolone derivatives on the level of reduced glutathione in rat liver].},
  author={Erika Bien},
  journal={Biomedica biochimica acta},
  year={1983},
  volume={42 5},
  pages={
          561-71
        }
}
  • Erika Bien
  • Published 1983
  • Chemistry, Medicine
  • Biomedica biochimica acta
  • The pyrazolone derivatives aminophenazone, phenazone, and propyphenazone are capable of decreasing reduced glutathione (GSH) in the liver after a single dose of 3 mmol/kg. The strongest effect is seen in female animals treated with propyphenazone. The depletion can be caused by (1) consumption during phase I of biotransformation, if reactive side products are inactivated by GSH-peroxidase, (2) consumption during phase II of biotransformation, if reactive metabolites are conjugated with GSH by… CONTINUE READING