• DOI:10.1254/FPJ.95.2_55
• Corpus ID: 22483650

[Effect of propiverine hydrochloride on the function of the bladder in decerebrated dogs].

@article{Kaneko1990EffectOP,
  title={[Effect of propiverine hydrochloride on the function of the bladder in decerebrated dogs].},
  author={Shuji Kaneko and Koutarou Kitazato and Y. Yamazaki and Hiroki Okada and Masanori Nagai and Masami Iriki},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  year={1990},
  volume={95 2},
  pages={
          55-61
        }
}

• S. Kaneko, K. Kitazato, +3 authors M. Iriki
• Published 1 February 1990
• Medicine, Biology, Chemistry
• Nihon yakurigaku zasshi. Folia pharmacologica Japonica

The effect of propiverine hydrochloride (P-4) on the function of the bladder in decerebrated dogs was compared with that of propantheline, an anticholinergic drug which is used for the treatment of micturitional disorders. P-4 (5 and 10 mg/kg, i.v.) significantly increased maximum vesical volume (Vmax); and at the dose of 10 mg/kg, i.v., it also significantly increased effective vesical volume (EV) when determined by cystometry. However, at the dose level of 2, 5 and 10 mg/kg, i.v., P-4 had no effect on residual volume (RV) after micturition contraction. Propantheline (0.25 and 0.5 mg/kg, i.v.) also significantly increased Vmax, but showed no effect on EV. At doses higher than 0.016 mg/kg, i.v., propantheline significantly increased RV. These findings indicate that P-4 is a useful drug for the treatment of pollakiuria.