[Effect of propiverine hydrochloride on the function of the bladder in decerebrated dogs].

  title={[Effect of propiverine hydrochloride on the function of the bladder in decerebrated dogs].},
  author={Shuji Kaneko and Koutarou Kitazato and Y. Yamazaki and Hiroki Okada and Masanori Nagai and Masami Iriki},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  volume={95 2},
  • S. Kaneko, K. Kitazato, M. Iriki
  • Published 1 February 1990
  • Medicine, Biology, Chemistry
  • Nihon yakurigaku zasshi. Folia pharmacologica Japonica
The effect of propiverine hydrochloride (P-4) on the function of the bladder in decerebrated dogs was compared with that of propantheline, an anticholinergic drug which is used for the treatment of micturitional disorders. P-4 (5 and 10 mg/kg, i.v.) significantly increased maximum vesical volume (Vmax); and at the dose of 10 mg/kg, i.v., it also significantly increased effective vesical volume (EV) when determined by cystometry. However, at the dose level of 2, 5 and 10 mg/kg, i.v., P-4 had no… 
2 Citations
Kinetics of propiverine as assessed by radioreceptor assay in poor and extensive metabolizers of debrisoquine
The poor and extensive metabolizers of debrisoquine did not differ significantly with regard to the concentration time behaviour of the active drug components, pattern of major metabolites, adverse drug reactions or any pharmacodynamic parameters measured.
In‐vitro Binding of Propiverine Hydrochloride and Some of its Metabolites to Serum Albumin in Man
Because attempts to assess the albumin‐binding of propiverine have produced conflicting results, the binding parameters of the drug and some of its metabolites to serum albumin in man have been re‐evaluated.


The effects of some anticholinergic compounds on the infused urinary bladder of unanaesthetized rabbits.
  • C. Sjögren
  • Medicine, Chemistry
    Acta pharmacologica et toxicologica
  • 1976
It was concluded that the peripheral actions of the substances used were confined mainly to the cholinergic receptors in the urinary bladder, and the different response after atropine was attributed to its central stimulating effect.
Emepronium bromide (Cetiprin). Its effect on bladder pressure and urinary flow in healthy subjects.
The effect of a quaternary nitrogen compound, Emepronium bromide (Cetiprin), on micturition parameters was investigated and all subjects developed residual urine together with an increase in pulse rate after the administration of the drug.
[The spasmolytic activity of propiverine and some of its structural analogs].
It could be demonstrated that the antispasmodic properties of propiverine were, in contrast to its methyl ether analogue, not only based on a blockade of muscarinic receptors but were also a consequence of nonspecific papaverine-like effects.
Anticholinergic and calcium antagonistic effects of terodiline in rabbit urinary bladder.
The results suggest that terodiline in low concentrations has mainly an antimuscarinic action, which makes it an effective inhibitor of bladder contraction, and an interesting tool for investigations of bladder contractility.
The effects of nifedipine and verapamil on spontaneous and carbachol-stimulated contractions of rat urinary bladder "in vivo".
The results suggest that the effects of verapamil on rat urinary bladder "in vivo" are different from those of nifedipine, and nifingipine on the contrary of verapsil only slightly antagonized the intensity of spontaneous contractions and of carbachol contracture.
Calcium antagonistic effects of terodiline in rabbit aorta and human uterus.
It is suggested that terodilines, which structurally has similarities to prenylamine and fendiline, like these drugs can be classified as a calcium antagonist.