[Effect of prednisolon, vincristine and mitoxantrone on glucocorticoid receptor in HL-60 cell line].

Abstract

The effects of prednisolon, vincristine and Mitoxantrone on glucocorticoid receptor (GCR) content and affinity were examined in HL-60 cell line with a whole-cell assay in vitro. The fall in GCR number was observed following a short time exposure to prednisolon, vincristine or Mitoxantrone alone. The significant decrease occurred in a dose-dependent (10(-8… (More)

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