• Chemistry, Medicine
  • Published in
    Zhongguo wei zhong bing ji…
    2007

[Effect of platelet activating factor receptor antagonist on the tight junction associated protein between the epithelial cells of intestinal mucosa during endotoxemia in young rats].

@article{Wang2007EffectOP,
  title={[Effect of platelet activating factor receptor antagonist on the tight junction associated protein between the epithelial cells of intestinal mucosa during endotoxemia in young rats].},
  author={Li-jie Wang and Mei Sun},
  journal={Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue},
  year={2007},
  volume={19 8},
  pages={
          477-80
        }
}
OBJECTIVE To investigate the effect of platelet activating factor (PAF) on the beta-catenin between the epithelial cells of intestinal mucosa during endotoxemia in rats, and to explore the mechanism of prospective effect of PAF receptor antagonist on intestinal epithelial barrier integrity. METHODS Rat model of endotoxemia was reproduced by intraperitoneal injection of lipopolysaccharide (LPS). Rats receiving PAF receptor antagonist BN52021 5 mg/kg before and 30 minutes after LPS injection… CONTINUE READING