• Medicine, Chemistry
  • Published in
    Archiv fur…
    1985

[Effect of nontoxic inhibitors on the nitrosation of drugs under conditions simulating the human stomach].

@article{Ziebarth1985EffectON,
  title={[Effect of nontoxic inhibitors on the nitrosation of drugs under conditions simulating the human stomach].},
  author={D M Ziebarth and T. Schramm},
  journal={Archiv fur Geschwulstforschung},
  year={1985},
  volume={55 2},
  pages={
          81-91
        }
}
The influence of sulphamic acid, sulfanilamide, p-aminosalicylic acid and ascorbic acid on the nitrosation behaviour of Analgin (active agent: noramidopyrinmethane sulfonate) was investigated in the pH range between 1.2 and 6.0 under simulated conditions of the human stomach. Using a colorimetric measuring method, the three last-mentioned compounds proved suitable as nitrosation inhibitors; preference should be given to ascorbic acid because of its better inhibitory capacity in the very weakly… CONTINUE READING