Corpus ID: 25469538

[Effect of nontoxic inhibitors on the nitrosation of drugs under conditions simulating the human stomach].

@article{Ziebarth1985EffectON,
  title={[Effect of nontoxic inhibitors on the nitrosation of drugs under conditions simulating the human stomach].},
  author={D. Ziebarth and T. Schramm},
  journal={Archiv fur Geschwulstforschung},
  year={1985},
  volume={55 2},
  pages={
          81-91
        }
}
The influence of sulphamic acid, sulfanilamide, p-aminosalicylic acid and ascorbic acid on the nitrosation behaviour of Analgin (active agent: noramidopyrinmethane sulfonate) was investigated in the pH range between 1.2 and 6.0 under simulated conditions of the human stomach. Using a colorimetric measuring method, the three last-mentioned compounds proved suitable as nitrosation inhibitors; preference should be given to ascorbic acid because of its better inhibitory capacity in the very weakly… Expand
Chromosomal aberrations induced by imipramine and desipramine in mouse
TLDR
The results agree with previous studies regarding the induction of micronuclei and sister chromatid exchanges by the drugs in mouse and suggest caution with respect to their use in long-term treatments. Expand