[Effect of nitroquine (CL-679) in vitro on incorporation of [3H]hypoxanthine into DNA and RNA of Plasmodium yoelii].

@article{Pang1988EffectON,
  title={[Effect of nitroquine (CL-679) in vitro on incorporation of [3H]hypoxanthine into DNA and RNA of Plasmodium yoelii].},
  author={Leon Pang and Ya-e Hu},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1988},
  volume={9 4},
  pages={
          349-52
        }
}
  • Leon Pang, Ya-e Hu
  • Published in
    Zhongguo yao li xue bao = Acta pharmacologica…
    1988
The effect of nitroquine acetate, together with pyrimethamine, was studied with [3H]hypoxanthine incorporation into DNA and RNA of Plasmodium yoelii during incubation in Men Eagle medium containing neither PABA nor folic acid. Incorporation into RNA was only slightly affected by nitroquine 10 vmol/L, whereas incorporation into DNA was markedly inhibited by nitroquine 0.1 nmol/L and pyrimethamine I nmol/L. When both drugs were at 10 vmol/L, inhibition of DNA synthesis was noted after 15 min of… CONTINUE READING

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