Corpus ID: 20263775

[Effect of methotrexate on the immune response in selected experimental models].

  title={[Effect of methotrexate on the immune response in selected experimental models].},
  author={Michał Zimecki and Jolanta Artym},
  journal={Postepy higieny i medycyny doswiadczalnej},
  • M. Zimecki, J. Artym
  • Published 2004
  • Medicine, Physics
  • Postepy higieny i medycyny doswiadczalnej
Methotrexate (MTX) is one of the immunosuppressory compounds applied in the prophylaxis and treatment of several diseases, including: rheumatoid arthritis, systemic lupus erythematosus, psoriasis, graft-versus-host disease and, in combination with other drugs, neoplastic diseases. Studies in humans and in animal model, of clinical disease, have demonstrated that MTX diminishes the clinical symptoms of various immunological disorders. MTX, an antagonist of folic acid synthesis, causes apoptosis… Expand
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