Corpus ID: 20263775

[Effect of methotrexate on the immune response in selected experimental models].

@article{Zimecki2004EffectOM,
  title={[Effect of methotrexate on the immune response in selected experimental models].},
  author={Michał Zimecki and Jolanta Artym},
  journal={Postepy higieny i medycyny doswiadczalnej},
  year={2004},
  volume={58},
  pages={
          226-35
        }
}
  • M. Zimecki, J. Artym
  • Published 2004
  • Medicine, Physics
  • Postepy higieny i medycyny doswiadczalnej
Methotrexate (MTX) is one of the immunosuppressory compounds applied in the prophylaxis and treatment of several diseases, including: rheumatoid arthritis, systemic lupus erythematosus, psoriasis, graft-versus-host disease and, in combination with other drugs, neoplastic diseases. Studies in humans and in animal model, of clinical disease, have demonstrated that MTX diminishes the clinical symptoms of various immunological disorders. MTX, an antagonist of folic acid synthesis, causes apoptosis… Expand
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References

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TLDR
It may be that the major direct effect of MTX on epidermal cell proliferation is complemented or even mediated by subtle immunoregulatory effects on the melange of cells in the affected skin and the systemic immune response. Expand
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.
TLDR
The data demonstrate that MTX can selectively delete activated peripheral blood T cells by a CD95-independent pathway, and this property could be used as a new pharmacological end point to optimize dosage and timing of MTX administration. Expand
Methotrexate treatment in murine experimental systemic lupus erythematosus (SLE); clinical benefits associated with cytokine manipulation
TLDR
The studies demonstrate therapeutic effects of MTX on murine experimental SLE and the normal cytokine profile observed following treatment with MTX is suggested to play a role in the amelioration of the clinical manifestations of experimental Sle. Expand
Comparative effects on the immune system of methotrexate and trimetrexate.
TLDR
While TMQ appeared to be more immunosuppressive than MTX following in vitro addition of the drugs, the converse seemed to be true when dosing was performed in vivo, the drug induced suppression of T-dependent antibody formation was dose dependent for both antifolates. Expand
Cytokine manipulation by methotrexate treatment in murine experimental systemic lupus erythematosus.
TLDR
The restoration of the cytokine profile to normal levels observed in the MTX treated mice from the initial steps of disease induction suggests its beneficial effects in SLE might be mediated through modulation of cytokine production. Expand
Differential effects of FK506 and methotrexate on inflammatory cytokine levels in rat adjuvant-induced arthritis.
TLDR
FK506 is more effective than MTX in reducing elevated levels of inflammatory cytokines TNF-a, IL-1beta, and IL-6 in established stages of AIA, and inhibition of T cell activation results in a rapid reduction ofinflammatory cytokine levels even after the arthritis is established in AIA. Expand
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TLDR
It is demonstrated that methotrexate is capable of inhibiting some IL-1 activities without affectingIL-1 production or secretion, and proposed that the inhibition of IL- 1 activity or IL-2-dependent events may be one of the mechanisms of action of MTX in RA. Expand
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TLDR
MTX induces apoptosis in RAsynovium that, in turn, may contribute to its antiinflammatory effect on RA synovitis. Expand
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TLDR
Inhibition of T cell cytokine production by MPA was more profound and started earlier compared to the inhibition by MTX, and that MPA reversibly prevents activation of T cells could explain the immunosuppressive effects of both these drugs. Expand
Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritis
TLDR
Methotrexate reduces the production of IL-6 by activated cells, and this may be responsible for its anti-inflammatory property. Expand
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