[Effect of metal ions Co2+ and Cr3+ on osteoblast apoptosis, cell cycle distribution, and secretion of alkaline phosphatase].

@article{Dai2011EffectOM,
  title={[Effect of metal ions Co2+ and Cr3+ on osteoblast apoptosis, cell cycle distribution, and secretion of alkaline phosphatase].},
  author={Min Dai and Tonghua Zhou and Hao Xiong and Wennan Zou and Ping Zhan and Wenfeng Fu},
  journal={Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery},
  year={2011},
  volume={25 1},
  pages={56-60}
}
OBJECTIVE Metal wear products cause the aseptic loosening of joint prosthesis. To investigate the effect of metal ions Co2+ and Cr3 on the osteoblast apoptosis, cell cycle distribution, and secretion of alkaline phosphatase (ALP), and to search a method to prevent and treat aseptic loosening. METHODS The mouse calvarial osteoblasts (MC3T3-E1) were cultured in vitro to 3-5 generations (5 x 10(5) cells/mL) and divided into 2 groups: the experimental group and the control group. The osteoblasts… CONTINUE READING

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