[Effect of high mobility group box 1 (HMGB1) in cultured human periodontal ligament cells].

  title={[Effect of high mobility group box 1 (HMGB1) in cultured human periodontal ligament cells].},
  author={Nami Hasegawa},
  journal={Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan},
  volume={75 3},
  • N. Hasegawa
  • Published 2008
  • Biology, Medicine
  • Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan
The periodontal ligament (PDL) is a fibrous connective tissue that exists in the cementum and the alveolar bone. Periodontitis is a chronic inflammatory disease that is caused by a bacterial infection in the periodontal region. This infection increases the production of inflammatory cytokines and causes the destruction of periodontal tissue. High mobility group box 1 (HMGB1) is a nuclear nonhiston DNA-binding protein that is present in many eukaryotic cells. HMGB1 is released actively from… 
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