[Effect of high mobility group box 1 (HMGB1) in cultured human periodontal ligament cells].

@article{Hasegawa2008EffectOH,
  title={[Effect of high mobility group box 1 (HMGB1) in cultured human periodontal ligament cells].},
  author={Nami Hasegawa},
  journal={Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan},
  year={2008},
  volume={75 3},
  pages={
          155-61
        }
}
  • N. Hasegawa
  • Published 2008
  • Biology, Medicine
  • Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan
The periodontal ligament (PDL) is a fibrous connective tissue that exists in the cementum and the alveolar bone. Periodontitis is a chronic inflammatory disease that is caused by a bacterial infection in the periodontal region. This infection increases the production of inflammatory cytokines and causes the destruction of periodontal tissue. High mobility group box 1 (HMGB1) is a nuclear nonhiston DNA-binding protein that is present in many eukaryotic cells. HMGB1 is released actively from… 
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High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
TLDR
The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri -implant tissue.
Expression of HMGB1 and HMGN2 in gingival tissues, GCF and PICF of periodontitis patients and peri-implantitis
TLDR
The first study reporting that the expression of HMGB1 and HMGN2 was increased in the gingival tissues and GCF in CP and G-AgP and the PicF in PICF suggests that HMGB 1 may be a potential target for the therapy of periodontitis and PI.
Expression of HMGB1 and HMGN2 in gingival tissues, GCF and PICF of periodontitis patients and peri-implantitis.
Dicarbonyl stress and dysfunction of the glyoxalase system in periodontal diseases
TLDR
It is revealed that dicarbonyl stress is a potential contributory pathogenic mechanism in hPDLFs in periodontitis and countering it may provide new treatment options to prevent and treat decline inperiodontal health, particularly in diabetes.
Effect of Periodontal Treatment on the Crevicular Level of High-mobility Group Box 1 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Patients with Chronic Periodontitis.
TLDR
Higher levels of high-mobility group box 1(HMGB1) and soluble triggering receptor expressed on myeloid cells (sTREM1) in the gingival crevicular fluid (GCF) of periodontitis patients and the significant decrease after the introduction of the periodontal treatment underlines the importance of HMGB1 and sTREM 1 in pathogenesis of periodentitis.
Expression of HMGB1 and NF-κB p65 and its significance in non-small cell lung cancer
TLDR
HMGB1 and NF-κB p65 expression may be related to non-small cell lung cancer metastasis.

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