[Effect of high mobility group box 1 (HMGB1) in cultured human periodontal ligament cells].
@article{Hasegawa2008EffectOH, title={[Effect of high mobility group box 1 (HMGB1) in cultured human periodontal ligament cells].}, author={Nami Hasegawa}, journal={Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan}, year={2008}, volume={75 3}, pages={ 155-61 } }
The periodontal ligament (PDL) is a fibrous connective tissue that exists in the cementum and the alveolar bone. Periodontitis is a chronic inflammatory disease that is caused by a bacterial infection in the periodontal region. This infection increases the production of inflammatory cytokines and causes the destruction of periodontal tissue. High mobility group box 1 (HMGB1) is a nuclear nonhiston DNA-binding protein that is present in many eukaryotic cells. HMGB1 is released actively from…
6 Citations
High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
- Biology, MedicineScientific Reports
- 2017
The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri -implant tissue.
Expression of HMGB1 and HMGN2 in gingival tissues, GCF and PICF of periodontitis patients and peri-implantitis
- Medicine, BiologyBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
- 2011
The first study reporting that the expression of HMGB1 and HMGN2 was increased in the gingival tissues and GCF in CP and G-AgP and the PicF in PICF suggests that HMGB 1 may be a potential target for the therapy of periodontitis and PI.
Expression of HMGB1 and HMGN2 in gingival tissues, GCF and PICF of periodontitis patients and peri-implantitis.
- MedicineArchives of oral biology
- 2011
Dicarbonyl stress and dysfunction of the glyoxalase system in periodontal diseases
- Biology, Medicine
- 2016
It is revealed that dicarbonyl stress is a potential contributory pathogenic mechanism in hPDLFs in periodontitis and countering it may provide new treatment options to prevent and treat decline inperiodontal health, particularly in diabetes.
Effect of Periodontal Treatment on the Crevicular Level of High-mobility Group Box 1 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Patients with Chronic Periodontitis.
- MedicineIranian journal of allergy, asthma, and immunology
- 2017
Higher levels of high-mobility group box 1(HMGB1) and soluble triggering receptor expressed on myeloid cells (sTREM1) in the gingival crevicular fluid (GCF) of periodontitis patients and the significant decrease after the introduction of the periodontal treatment underlines the importance of HMGB1 and sTREM 1 in pathogenesis of periodentitis.
Expression of HMGB1 and NF-κB p65 and its significance in non-small cell lung cancer
- Medicine, BiologyContemporary oncology
- 2013
HMGB1 and NF-κB p65 expression may be related to non-small cell lung cancer metastasis.
References
SHOWING 1-10 OF 27 REFERENCES
Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines.
- Biology, MedicineArteriosclerosis, thrombosis, and vascular biology
- 2004
Activation of Human Umbilical Vein Endothelial Cells Leads to Relocation and Release of High‐Mobility Group Box Chromosomal Protein 1
- Biology, MedicineScandinavian journal of immunology
- 2004
HUVEC may be an important source of HMGB1 secretion in response to systemic infection and that endothelial cells and monocytes may use different signalling pathways.
High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine.
- Medicine, BiologyArthritis and rheumatism
- 2003
HMGB-1 was more strongly expressed in SF of RA patients than in that of OA patients, inducing the release of proinflammatory cytokines from SFMs.
Transforming growth factor-beta stimulates interleukin-11 production by human periodontal ligament and gingival fibroblasts.
- Biology, MedicineJournal of clinical periodontology
- 2006
It is suggested that PDL produce IL-11 in response to TGF-beta, with higher values in PDL than previously thought.
Interleukin-11 and IL-17 and the pathogenesis of periodontal disease.
- MedicineJournal of periodontology
- 2004
Gingival concentrations of IL-11 and IL-17 are different in diseased gingiva adjacent to 3, 4 to 5, and > or = 6 mm pockets, suggesting that their concentrations change as a consequence of the progression of gingivitis to periodontitis and that both cytokines could have a significant role in this progression.
Investigation of multipotent postnatal stem cells from human periodontal ligament
- Biology, MedicineThe Lancet
- 2004
Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes.
- Biology, MedicineSurgery
- 1999
HMG-1 as a late mediator of endotoxin lethality in mice.
- Biology, MedicineScience
- 1999
High mobility group-1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1, and showed increased serum levels after endotoxin exposure, suggesting that this protein warrants investigation as a therapeutic target.
Autocrine down-regulation of glucocorticoid receptors by interleukin-11 in human osteoblast-like cell lines.
- Biology, MedicineThe Journal of endocrinology
- 2003
The concept of autocrine-paracrine loops that modulate GC action and involve gp130 cytokines is corroborated and could have clinical relevance for the dynamics of bone loss in patients given GC and having high concentrations of these cytokines in the bone microenvironment.
A Comparative Study of Human Periodontal Ligament Cells and Gingival Fibroblasts in vitro
- Medicine, BiologyJournal of dental research
- 1988
This work compared human periodontal ligament cells and gingival fibroblasts, both derived from the same patient, same passage, in vitro and found that protein and collagen production was significantly greater in periodontals when compared with that of gingivals.