[Effect of high doses of tissue plasminogen activator on the hemostatic and fibrinolytic systems].

Intravenous administration of tissue activator plasminogen (TAP), isolated from a frozen pig heart using the technique of Bachman et al., to white rats produced considerable fibrinolysis activation in the euglobulin fraction only. The clot lysis time of this fraction was reduced 2.4-fold within 10 minutes after TAP administration, and high levels of the… CONTINUE READING