• Medicine
  • Published in
    Zhurnal evoliutsionnoi…
    2013

[Effect of diazoxide on the AS-30D rat ascites hepatoma cells treated by Cd2+].

@article{Beliaeva2013EffectOD,
  title={[Effect of diazoxide on the AS-30D rat ascites hepatoma cells treated by Cd2+].},
  author={E A Beliaeva},
  journal={Zhurnal evoliutsionnoi biokhimii i fiziologii},
  year={2013},
  volume={49 5},
  pages={
          340-7
        }
}
For the last years, in several investigations, including ours, it was shown that oxidative stress and mitochondrial dysfunction mediated by disturbance of the mitochondrial respiratory chain and by induction of Ca2+ -dependent nonselective high-conductance pore of the inner mitochondrial membrane are involved in mechanism(s) of cytotoxic action of heavy metals. At the same time, possible interaction of heavy metals with other channels, in particular, with selective potassium channels, such as… CONTINUE READING