[Effect of cranial irradiation on the blood-cerebrospinal fluid and blood-brain barrier].

@article{Ludwig1987EffectOC,
  title={[Effect of cranial irradiation on the blood-cerebrospinal fluid and blood-brain barrier].},
  author={R. Ludwig},
  journal={Klinische Padiatrie},
  year={1987},
  volume={199 3},
  pages={
          233-8
        }
}
  • R. Ludwig
  • Published 1 May 1987
  • Medicine
  • Klinische Padiatrie
The influence of fractionated cranial irradiation with 24 Gy on blood-CSF and blood-brain barrier permeability for methotrexate (MTX) and serum proteins was studied in young rabbits. In unirradiated control animals and 1, 4, 14 and 26 weeks following cranial irradiation MTX 57.5 mg/kg body weight was given by an infusion. 24 hours after the start of the MTX-infusion blood, CSF and brain was collected. MTX was measured by a radioimmunoassay, albumin and IgG by immunnephelometry. MTX in serum and… Expand
Changes in blood-brain barrier permeability induced by radiotherapy: implications for timing of chemotherapy? (Review).
TLDR
A review on the effects of irradiation on the blood-brain barrier (BBB) is presented and the potential value for therapeutic applications is discussed. Expand