[Effect of ZGDHu-1 on proliferation and apoptosis of A549 cells in vitro and antitumor activity in vivo].

@article{Zhou2007EffectOZ,
  title={[Effect of ZGDHu-1 on proliferation and apoptosis of A549 cells in vitro and antitumor activity in vivo].},
  author={Yong-Lie Zhou and Wei-xiao Hu and Ya-ping L{\"u} and Lian-n{\"u} Qiu and Wen-song Wang and Zhong-Yu Yang and Jian-dong Liu and G. B. Dharma Rao},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  year={2007},
  volume={42 1},
  pages={26-34}
}
This study is to explore the mechanism and effect of N, N'-di-(m-methylphenyl)-3, 6-dimethyl-1, 4-dihydro-1, 2, 4, 5-tetrazine-1, 4-dicarboamide (ZGDHu-1) on proliferation and apoptosis of A549 cells in vitro and on A549 xenograft tumor in nude mice. With different concentrations of ZGDHu-1 at different times were used to treat A549 cells in vitro. The proliferation was determined by living cell count, SRB assay and Brdu-ELISA. Cell apoptosis was determined by cell morphology, DNA agarose gel… CONTINUE READING
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