[Effect of NF-kappaB on inhibition of non-small cell lung cancer cell cyclooxygenase-2 by brucine].

Abstract

OBJECTIVE To study the molecular mechanism of cyclooxygenase-2 (COX-2), one of effective ingredient of brucine, in inducing non-small cell lung cancer cell apoptosis. METHOD COX-2 promoter, transcription factor deletion mutants and COX-2 mRNA 3'-UTR-containing report plasmids were transfected with Renillia to non-small cell lung cancer A549 cell, in order… (More)

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