[Effect of Metformin on Proliferation of Multiple Myeloma Cells].


OBJECTIVE To investigate the effects of metformin on proliferation and apoptosis in multiple myeloma cell line RPMI8226 and U266, and to clarify the molecular mechanism of proliferation inhibition and apoptosis induced by metformin. METHODS RPMI8226, U266 cells were treated with 0, 5, 10, 20, 40, 80 mmol/L of metformin for 24, 48 and 72 hours, then the… (More)
DOI: 10.7534/j.issn.1009-2137.2017.04.024


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