[Effect of Emodin Combined with AZT on the Proliferation and the Expression of BCL-2, NF-κB, TGF-β in the Leukemia Stem Cells-KG-1a cells].

@article{Wang2015EffectOE,
  title={[Effect of Emodin Combined with AZT on the Proliferation and the Expression of BCL-2, NF-κB, TGF-β in the Leukemia Stem Cells-KG-1a cells].},
  author={L. Wang and Zi-Jian Li and Ya-ming Xi and Che Chen and T. Ma and L. Zhao and Ming-feng Jia and M. Li and H. Zhang and C. Liu},
  journal={Zhongguo shi yan xue ye xue za zhi},
  year={2015},
  volume={23 5},
  pages={
          1265-71
        }
}
  • L. Wang, Zi-Jian Li, +7 authors C. Liu
  • Published 2015
  • Biology, Medicine
  • Zhongguo shi yan xue ye xue za zhi
  • OBJECTIVE To investigate the effect of Emodin combined with 3'-azido-3'-deoxythymidine (AZT) on the proliferation and apoptosis of concentrated leukemia stem cells (CLSC)-human acute myeloid leukemia KG-la cells and expression of BCL-2, NF-κB and TGF-β. METHODS The tumor stem cell-like subpopulation in human leukemia cell line KG-1a was enriched with 5-fluorouracil (5-FU). The CD34⁺ CD38⁻ subpopulation in the KG-1a cells was detected with flow cytometry, the cell proliferation was detected by… CONTINUE READING
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