[Effect of As₂O₃on Hedgehog Pathway in Chronic Myeloid Leukemia Cells].

Abstract

OBJECTIVE To explore the effect of As₂O₃on Hedgehog pathway in chronic myeloid leukemia (CML) cells. METHODS The apoptosis of K562 cells was detected by MTT method and flow cytometry; the expressions of PTCH and SMO protein and mRNA in Hedgehog pathway were determined by Western blot and real-time PCR, respectively. Retults: The As₂O₃ could induce the… (More)
DOI: 10.7534/j.issn.1009-2137.2015.04.012

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