[Down-regulation of Notch1 by small interfering RNA enhances chemosensitivity to gemcitabine in pancreatic cancer cells through activating apoptosis activity].

@article{Du2014DownregulationON,
  title={[Down-regulation of Notch1 by small interfering RNA enhances chemosensitivity to gemcitabine in pancreatic cancer cells through activating apoptosis activity].},
  author={Xiao Xue Du and Yi-han Wang and Zi-qiang Wang and Zhong Cheng and Yang Li and Jian-kun Hu and Zhi-xin Chen and Zongguang Zhou},
  journal={Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences},
  year={2014},
  volume={43 3},
  pages={313-8}
}
OBJECTIVE To investigate the effect of down-regulation of Notch1 by Notch1 small interfering RNA (siRNA) on chemosensitivity to gemcitabine in pancreatic cancer cells and its mechanism. METHODS Notch1 siRNA was transfected to pancreatic cancer cell lines AsPC-1, BxPC-3, MIAPaCa-2 and Panc-1. The transfected pancreatic cancer cells were treated with 10… CONTINUE READING