[Do antisense oligonucleotides improve viral immunopathology?].


BACKGROUND Tumor necrosis factor (TNF)-alpha as a proinflammatory cytokine is of great importance during the development of herpes simplex virus-1 keratitis (HSK). In this study the local administration of antisense oligonucleotides (ASON) targeting TNF-alpha was examined for its usefulness in ameliorating this disease. METHODS Uptake and efficacy of the… (More)


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