[Distribution of gentamicin in inner ear after intratympanic gentamicin injection].

Abstract

OBJECTIVE To investigate uptake and accumulation of gentamicin by cells in the guinea pig inner ear after intratympanic injection using a fluorescent probe--gentamicin-Texas-red conjunction (GTTR). METHODS Adult guinea pigs (n = 80) were administered a single dose of GTrR to the middle ear cavity through the intact membrane and survived for 12 h, 24 h, 48… (More)

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