[Disposition behavior and absorption mechanism of trientine, an orphan drug for Wilson's disease].

@article{Tanabe1996DispositionBA,
  title={[Disposition behavior and absorption mechanism of trientine, an orphan drug for Wilson's disease].},
  author={Ryo-ichi Tanabe},
  journal={[Hokkaido igaku zasshi] The Hokkaido journal of medical science},
  year={1996},
  volume={71 2},
  pages={217-28}
}
  • Ryo-ichi Tanabe
  • Published 1996 in
    [Hokkaido igaku zasshi] The Hokkaido journal of…
The disposition behavior of trientine, a selective copper-chelating drug for Wilson's disease, and its metabolites in normal patients with Wilson's disease and rats were studied. A high concentration of metabolites appeared in blood samples of patients and rats in the early stage after administration of trientine. Furthermore, large amount of trientine metabolites were excreted into the urine of patients. These results suggest that trientine is remarkably subjected to a first-pass effect. The… CONTINUE READING