[Discovery of potential LXRβ agonists from Chinese herbs using molecular simulation methods].

Abstract

Liver X receptor β (LXRβ) has been a new target in the treatment of hyperlipemia, which was related to the cholesterol homeostasis. In this study, the quantitative pharmacophores were constructed by 3D-QSAR pharmacophore (Hypogen) method based on the LXRβ agonists. The optimal pharmacophore model containing one hydrogen bond acceptor, two hydrophobics and… (More)
DOI: 10.4268/cjcmm20161621

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Cite this paper

@article{Luo2016DiscoveryOP, title={[Discovery of potential LXRβ agonists from Chinese herbs using molecular simulation methods].}, author={Ganggang Luo and Fang Lu and Lian-sheng Qiao and Yong Li and Yanling Zhang}, journal={Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica}, year={2016}, volume={41 16}, pages={3065-3071} }