[Dihydrotestosterone and the role of 5 alpha-reductase inhibitors in benign prostatic hyperplasia].

@article{Bartsch2002DihydrotestosteroneAT,
  title={[Dihydrotestosterone and the role of 5 alpha-reductase inhibitors in benign prostatic hyperplasia].},
  author={Georg Bartsch and Roger S. Rittmaster and Helmut Klocker},
  journal={Der Urologe. Ausg. A},
  year={2002},
  volume={41 5},
  pages={
          412-24
        }
}
The genesis of benign prostate hyperplasia (BPH) depends on two factors: testicular androgen and the aging process. The most important androgen in the prostate is dihydrotestosterone (DHT). In the aging male the level of DHT in the prostate remains largely constant although the plasma level of testosterone decreases. DHT is formed by the reduction of testosterone by the enzyme 5-alpha-reductase, which has two isoenzymes. The 5-alpha-reductase type 2 is the predominant isoenzyme in genital… CONTINUE READING

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