[Differences in the efficiency of their interaction with membrane receptors of the dialkylaminoalkyl and dialkylaminoacyl derivatives of phenothiazine].

@article{Saveleva1990DifferencesIT,
  title={[Differences in the efficiency of their interaction with membrane receptors of the dialkylaminoalkyl and dialkylaminoacyl derivatives of phenothiazine].},
  author={M. V. Savel'eva and Elizaveta I Ratner and G N Baldenko and Natalya V. Kaverina},
  journal={Biulleten' eksperimental'noi biologii i meditsiny},
  year={1990},
  volume={109 3},
  pages={266-8}
}
New dialkylaminoacyl phenothiazine derivatives (DAC) were compared with their dialkylaminoalkyl analogues (neuroleptics chlorpromazine, trifluoperazine and fluphenazine) as well as with anti-arrhythmia drugs ethmozine and ethacizine for their receptor-blocking potencies. It was established that DAC are significantly less potent with dopamine alpha 1-adrenergic and H1-histamine receptors of calf and rabbit brain, which can explain the absence of neuroleptic effect of DAC drugs. DAC affinities to… CONTINUE READING