[Difference of tolerances to isoprenaline between tracheal and vascular smooth muscles and cardiac conduction system in guinea pigs].


Pretreatment to guinea pigs with sc isoprenaline (Iso) 10 micrograms/kg tid x 7 d reduced the effect of Iso on protecting histamine-induced asthma and decreased its pD2 values in relaxing isolated tracheal strip. This treatment did not change the asthmatic effect induced by histamine and the effect of Iso on positive chronotropic action, but elevated the… (More)


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