[Diagnosis of cystic fibrosis; simple genotyping to rule out the disease preferable to starting with the sweat test].

@article{Bergh2003DiagnosisOC,
  title={[Diagnosis of cystic fibrosis; simple genotyping to rule out the disease preferable to starting with the sweat test].},
  author={Frank A T J M van den Bergh and Andreas Martens},
  journal={Nederlands tijdschrift voor geneeskunde},
  year={2003},
  volume={147 21},
  pages={1001-5}
}
For historical reasons, the sweat test remains the cornerstone in the diagnostic work-up for cystic fibrosis (CF). If CF is suspected, the sweat test (following pilocarpine iontophoresis) is usually performed first to confirm or rule out the diagnosis of CF. Sweat testing, however, is cumbersome to the patient, prone to technical difficulties and unreliable in young children < 4 weeks as well as in adults because of increasing chloride concentrations with age. False-positive and false-negative… CONTINUE READING